Raf1-RBD Agarose
| Catalog number: | B2018662 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 1 mL |
| Molecular Weight or Concentration: | N/A |
| Supplied as: | Suspension |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -80C |
| Keywords: | Raf1-RBD Agarose |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Xu X, Brzostowski J, Ramachandra S, Bhimani S, You Y, Jin T. Visualizing Key Signaling Components of Macropinocytosis and Phagocytosis Using Confocal Microscopy in the Model Organism Dictyostelium discoideum Methods Mol Biol. 2021;2304:193-205.
- Zhang Z, Gao R, Hu Q, Peacock H, Peacock DM, Dai S, Shokat KM, Suga H. GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf ACS Cent Sci. 2020 Oct 28;6(10):1753-1761.
- Tran TH, Chan AH, Young LC, Bindu L, Neale C, Messing S, Dharmaiah S, Taylor T, Denson JP, Esposito D, Nissley DV, Stephen AG, McCormick F, Simanshu DK. KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation Nat Commun. 2021 Feb 19;12(1):1176.
- Zheng Y, Ding L, Meng X, Potter M, Kearney AL, Zhang J, Sun J, James DE, Yang G, Zhou C. Structural insights into Ras regulation by SIN1 Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2119990119.
- Kazi A, Ranjan A, Kumar M V V, Agianian B, Garcia Chavez M, Vudatha V, Wang R, Vangipurapu R, Chen L, Kennedy P, Subramanian K, Quirke JCK, Beato F, Underwood PW, Fleming JB, Trevino J, Hergenrother PJ, Gavathiotis E, Sebti SM. Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors Cancer Res Commun. 2023 Dec 28;3(12):2623-2639.
- de Rooij J, Bos JL. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras Oncogene. 1997 Feb 6;14(5):623-5.
- Chao FA, Chan AH, Dharmaiah S, Schwieters CD, Tran TH, Taylor T, Ramakrishnan N, Esposito D, Nissley DV, McCormick F, Simanshu DK, Cornilescu G. Reduced dynamic complexity allows structure elucidation of an excited state of KRAS(G13D) Commun Biol. 2023 Jun 2;6(1):594.
- El Bouchikhi I, Belhassan K, Moufid FZ, Iraqui Houssaini M, Bouguenouch L, Samri I, Atmani S, Ouldim K. Noonan syndrome-causing genes: Molecular update and an assessment of the mutation rate Int J Pediatr Adolesc Med. 2016 Dec;3(4):133-142.
- Cui Y, Ma L, Schacke S, Yin JC, Hsueh YP, Jin H, Morrison H. Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway Hum Mol Genet. 2021 Feb 4;29(23):3793-3806.
