Polyclonal Antibody to Proteinase 3
| Catalog number: | B2018838 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 100 ug |
| Molecular Weight or Concentration: | N/A |
| Supplied as: | Powder |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | 2-8C |
| Keywords: | Polyclonal Antibody to Proteinase 3 |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Watorek E, Boratyska M, Klinger M. Wegeners granulomatosisautoimmunity to neutrophil proteinase 3 Arch Immunol Ther Exp (Warsz). 2003;51(3):157-67.
- Kelly S, Jackson KJ, Peters TJ, Suan D, Goodnow CC. Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences J Autoimmun. 2024 Jan;142:103129.
- Ballieux BE, Zondervan KT, Kievit P, Hagen EC, van Es LA, van der Woude FJ, Daha MR. Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC? Clin Exp Immunol. 1994 Jul;97(1):52-60.
- Granel J, Lemoine R, Morello E, Gallais Y, Mariot J, Drapeau M, Musnier A, Poupon A, Pugnire M, Seren S, Nouar D, Gouilleux-Gruart V, Watier H, Korkmaz B, Hoarau C. 4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis Front Immunol. 2020 Sep 25;11:573040.
- Colman R, Hussain A, Goodall M, Young SP, Pankhurst T, Lu X, Jefferis R, Savage CO, Williams JM. Chimeric antibodies to proteinase 3 of IgG1 and IgG3 subclasses induce different magnitudes of functional responses in neutrophils Ann Rheum Dis. 2007 May;66(5):676-82.
- Hussain A, Pankhurst T, Goodall M, Colman R, Jefferis R, Savage CO, Williams JM. Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fcgamma receptors Immunology. 2009 Oct;128(2):236-44.
- De Bandt M, Meyer O, Dacosta L, Elbim C, Pasquier C. Anti-proteinase-3 (PR3) antibodies (C-ANCA) recognize various targets on the human umbilical vein endothelial cell (HUVEC) membrane Clin Exp Immunol. 1999 Feb;115(2):362-8.
- Haubitz M, Gerlach M, Kruse HJ, Brunkhorst R. Endothelial tissue factor stimulation by proteinase 3 and elastase Clin Exp Immunol. 2001 Dec;126(3):584-8.
- Le Roux S, Pepper RJ, Dufay A, Nel M, Meffray E, Lamand N, Rimbert M, Josien R, Hamidou M, Hourmant M, Cook HT, Charreau B, Larger E, Salama AD, Fakhouri F. Elevated soluble Flt1 inhibits endothelial repair in PR3-ANCA-associated vasculitis J Am Soc Nephrol. 2012 Jan;23(1):155-64.
