Phe-Pro-Arg-Chloromethylketone
| Catalog number: | B2014446 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 5 mg |
| Molecular Weight or Concentration: | N/A |
| Supplied as: | Powder |
| Applications: | molecular tool for various biochemical applications |
| Storage: | 20C |
| Keywords: | Phe-Pro-Arg-Chloromethylketone |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Shan L. Alexa Fluor 680-NH-CO-CH(2)-S-CH(2)-Phe-Pro-Arg-CH(2)-prothrombin 2012 Mar 15 [updated 2012 May 15]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 20042013.
- Shan L. (64)Cu-Diethylenetriamine pentaacetic acid-NH-CO-CH(2)-S-CH(2)-Phe-Pro-Arg-CH(2)-prothrombin 2012 Mar 15 [updated 2012 May 15]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 20042013.
- Bode W. X-ray crystal structures of thrombin in complex with D-Phe-Pro-Arg and with small benzamidine- and arginine-based non-peptidic inhibitors Adv Exp Med Biol. 1993;340:15-26.
- Ilas J, Hudecz F, S_li-Vargha H, Kikelj D. Peptides and pseudopeptides incorporating D-Phe-Pro-Arg and Arg-Gly-Asp lead sequences as potential antithrombotic agents J Pept Sci. 2008 Aug;14(8):946-53.
- Skrzypczak-Jankun E, Rydel TJ, Tulinsky A, Fenton JW 2nd, Mann KG. Human D-Phe-Pro-Arg-CH2-alpha-thrombin crystallization and diffraction data J Mol Biol. 1989 Apr 20;206(4):755-7.
- Bajusz S, Szell E, Bagdy D, Barabas E, Horvath G, Dioszegi M, Fittler Z, Szabo G, Juhasz A, Tomori E, et al. Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H J Med Chem. 1990 Jun;33(6):1729-35.
- Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hffken HW. D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33.
- Bajusz S, Barabas E, Fauszt I, Feher A, Horvath G, Juhasz A, Szabo GA, Szell E. Active site-directed thrombin inhibitors: alpha-hydroxyacyl-prolyl-arginals, new orally active stable analogues of D-Phe-Pro-Arg-H Semin Thromb Hemost. 1996;22(3):243-6.
- Pathak M, Manna R, Li C, Kaira BG, Hamad BK, Belviso BD, Bonturi CR, Dreveny I, Fischer PM, Dekker LV, Oliva MLV, Emsley J. Crystal structures of the recombinant _-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics Acta Crystallogr D Struct Biol. 2019 Jun 1;75(Pt 6):578-591.
