Magnesium Ionophore VI Catalog B2024725
Magnesium Ionophore VI (ETH 5506) (Catalog B2024725) is a high-purity neutral ionophore supplied as 10 mg in solution. This lipophilic carrier is highly selective for Mg ions and is widely used in the construction of ion-selective electrodes (ISEs) for magnesium determination in biological, clinical, and environmental samples. It enables accurate, sensitive potentiometric detection of magnesium with minimal interference from other cations such as Ca, Na, and K.
| Catalog number: | B2024725 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 10 mg |
| Molecular Weight or Concentration: | 1033.47 g/mol |
| Supplied as: | Solution |
| Applications: | Construction of magnesium ion-selective electrodes (ISEs), potentiometric magnesium determination in biological fluids, clinical chemistry, environmental analysis, and sensor development |
| Storage: | Room Temperature (RT) |
| Keywords: | Magnesium Ionophore VI, ETH 5506, 1,3,5-Tris[10-(1-adamantyl)-7,9-dioxo-6,10-diazaundecyl]benzene, Mg ionophore |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
Scientific Overview
Magnesium Ionophore VI (ETH 5506) is a neutral, lipophilic ionophore with excellent selectivity for Mg over other physiologically relevant cations. It is incorporated into PVC-based membranes for ion-selective electrodes that provide rapid, accurate, and interference-free potentiometric measurement of magnesium ions. This ionophore is a standard choice in clinical chemistry analyzers, research laboratories, and sensor development for monitoring magnesium in serum, plasma, cell culture media, and environmental samples.
Key applications include:
- Magnesium-selective electrodes (ISEs) for clinical and research use
- Potentiometric determination of free and total magnesium
- Biochemical studies of magnesium homeostasis
- Environmental and industrial water analysis
- Development of advanced ion sensors and biosensors
Usage & Handling Guidance
Store at room temperature in a tightly sealed container. For membrane preparation, dissolve the ionophore in appropriate solvent (e.g., THF) along with PVC, plasticizer, and additives according to standard ISE protocols. Protect from moisture and light during long-term storage.
- Typical membrane composition: 13% (w/w) ionophore in PVC/plasticizer matrix
- Selectivity: High Mg selectivity over Ca, Na, K
- Stability: Stable when stored properly; follow manufacturer guidelines for electrode lifetime
What You Get
- 10 mg Magnesium Ionophore VI (ETH 5506)
- High-purity ionophore suitable for ion-selective electrode fabrication
- Excellent Mg selectivity for sensitive potentiometric measurements
- Convenient quantity for laboratory-scale sensor development
- For research use only (RUO)
Why Researchers Choose It
- Proven high selectivity for Mg in complex matrices
- Reliable performance in clinical and research magnesium ISEs
- High purity suitable for sensitive analytical applications
- Well-characterized ionophore with extensive literature support
- Essential tool for magnesium homeostasis and sensor research
Frequently Asked Questions (FAQ)
- What is Magnesium Ionophore VI used for?
It is primarily used to prepare magnesium-selective electrodes for potentiometric determination of Mg ions. - What is the chemical name / identifier?
ETH 5506; systematic name: 1,3,5-Tris[10-(1-adamantyl)-7,9-dioxo-6,10-diazaundecyl]benzene. - How should I store the product?
Store at room temperature (RT) in a tightly closed container, protected from moisture. - Is it suitable for clinical magnesium measurement?
Yes. It is widely used in clinical chemistry analyzers and research settings for accurate Mg detection. - What membrane components are typically used?
PVC matrix, plasticizer (e.g., DOS), and ionic additives; optimize according to published protocols.
This product is for Research Use Only (RUO). It is not intended for diagnostic or therapeutic use in humans or animals.
References
- Lanter F, Erne D, Ammann D, Simon W. Neutral carrier based ion-selective electrode for intracellular magnesium activity studies. Anal Chem. 1980;52(14):2400-2402.
- Oesch U, Brzzka Z, Xu A, Rusterholz B, Suter G, Pham HV, Welti DH, Ammann D, Pretsch E, Simon W. Design of neutral hydrogen ion carriers for solvent polymeric membrane electrodes of selected pH range. Anal Chem. 1986;58(13):2285-2289.
- Suzuki K, Watanabe K, Matsumoto Y, Kobayashi M, Sato S, Siswanta D, Hisamoto H. Design and synthesis of calcium and magnesium ionophores based on double-armed diazacrown ether compounds and their application to an ion sensing component for an ion-selective electrode. Anal Chem. 1995;67(2):324-334.
- Spichiger UE, Eugster R, Haase E, Rumpf G, Gehrig P, Schmid A, Rusterholz B, Simon W. Critical parameters and optimization of a magnesium-selective liquid membrane electrode for application to human blood serum. Fresenius J Anal Chem. 1991;341(12):727-731.
- Schaller U, Spichiger UE, Simon W. Novel magnesium ion-selective microelectrodes based on a neutral carrier. Pflgers Arch. 1993;423(5-6):338-342.
- Romani AMP. Cellular magnesium homeostasis. Arch Biochem Biophys. 2011 Aug 1;512(1):1-23.
- Schefer U, Ammann D, Pretsch E, Oesch U, Simon W. Neutral carrier based Ca2+-selective electrode with detection limit in the sub-nanomolar range. Anal Chem. 1986;58(11):2282-2285.
- Bhlmann P, Pretsch E, Bakker E. Carrier-based ion-selective electrodes and bulk optodes. 2. Ionophores for potentiometric and optical sensors. Chem Rev. 1998;98(4):1593-1688.
- Siswanta D, Hisamoto H, Sato S, Matsumoto Y, Koike Y, Yamamori S, Suzuki K. Magnesium ion-selective optodes based on a neutral ionophore and a lipophilic cationic dye. Anal Sci. 1997;13(3):429-435.
- Rouilly M, Rusterholz B, Spichiger UE, Simon W. Neutral ionophore-based selective electrode for assaying the activity of magnesium in undiluted blood serum. Clin Chem. 1990;36(3):466-469.
