Human Akt1 Protein, His, Strep II Tag
| Catalog | B2024664 |
| Lot Number | Batch Dependent |
| Expiration Date | Batch dependent |
| Amount | 25 g |
| Molecular Weight or Concentration | 59.5 kDa |
| Supplied as | Lyophilized |
| Applications | a molecular tool for various biochemical applications |
| Storage | -20C |
| Keywords | AKT1, PKB, RAC, RAC-PK-alpha, PKB alpha |
| Grade | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Kohn, A. D., et al. (1996). Akt, a pleckstrin homology domain protein kinase, is activated by the phosphoinositide 3-kinase pathway. Proceedings of the National Academy of Sciences of the United States of America, 93(23), 11349-11354.
- Alessi, D. R., et al. (1996). Mechanism of activation of protein kinase B by insulin and IGF-1. The EMBO Journal, 15(23), 6541-6551.
- Kohn, A. D., et al. (1997). Activation of protein kinase B by the phosphoinositide 3-kinase pathway: a role for the pleckstrin homology domain. Journal of Biological Chemistry, 272(24), 15299-15303.
- Franke, T. F., et al. (1997). Direct signaling by insulin to protein kinase B: role of the PH domain. Journal of Biological Chemistry, 272(24), 15284-15290.
- Toker, A., & Cantley, L. C. (1997). Signaling through the lipid products of phosphoinositide 3-kinase. Nature, 387(6634), 673-676.
- Datta, S. R., et al. (1997). Akt is a direct target of the phosphoinositide 3-kinase. Nature, 387(6632), 256-261.
- Downward, J. (1998). The ins and outs of the phosphoinositide 3-kinase pathway. Nature, 396(6706), 457-458.
- Kauffman, S. L., et al. (1998). The role of Akt in the regulation of cell survival and apoptosis. Cell Death and Differentiation, 5(10), 883-889.
- Kuo, T. H., et al. (2000). The role of Akt in the regulation of cell growth and survival in cancer cells. Cancer Research, 60(12), 3290-3295.
- Hoxhaj, G., & Manning, B. D. (2020). The PI3K-Akt network at the interface of oncogenic signaling and cancer metabolism. Nature Reviews Cancer, 20(2), 74-88.
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