Furin Human
| Catalog number: | B2018876 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 50 Units |
| Molecular Weight or Concentration: | 57 kDa |
| Supplied as: | Solution |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -80C |
| Keywords: | Dibasic-processing enzyme, Furin convertase, PACE, Paired basic amino acid residue-cleaving enzyme |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Osman EEA, Rehemtulla A, Neamati N. Why All the Fury over Furin? J Med Chem. 2022 Feb 24;65(4):2747-2784.
- Romeu AR. Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif BMC Genom Data. 2023 Nov 21;24(1):71.
- He Z, Khatib AM, Creemers JWM. The proprotein convertase furin in cancer: more than an oncogene Oncogene. 2022 Feb;41(9):1252-1262.
- Pacheco A, Issaian A, Davis J, Anderson N, Nemkov T, Paukovich N, Henen MA, Vgeli B, Sikela JM, Hansen K. Proteolytic activation of human-specific Olduvai domains by the furin protease Int J Biol Macromol. 2023 Apr 15;234:123041.
- Zhang Y, Gao X, Bai X, Yao S, Chang YZ, Gao G. The emerging role of furin in neurodegenerative and neuropsychiatric diseases Transl Neurodegener. 2022 Aug 23;11(1):39.
- Hoffmann M, Kleine-Weber H, Phlmann S. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells Mol Cell. 2020 May 21;78(4):779-784.e5.
- Douglas LEJ, Reihill JA, Montgomery BM, Martin SL. Furin as a therapeutic target in cystic fibrosis airways disease Eur Respir Rev. 2023 May 3;32(168):220256.
- Marafie SK, Al-Mulla F. An Overview of the Role of Furin in Type 2 Diabetes Cells. 2023 Oct 5;12(19):2407.
- Jaaks P, Bernasconi M. The proprotein convertase furin in tumour progression Int J Cancer. 2017 Aug 15;141(4):654-663.
