Dextran Conjugated to Texas Red

Dextran Conjugated to Texas Red Research Use Only

Texas Redlabeled dextrans are widely used fluorescent tracers for studying membrane permeability, endocytosis, intracellular trafficking, neuronal labeling, and macromolecular transport. This product line includes eight molecular weight variants (32000 kDa), enabling researchers to select sizedependent diffusion and uptake characteristics appropriate for their experimental system. Each conjugate is supplied as a biotechnologygrade solution, prepared in ultrapure water and sterilefiltered for reproducible performance in imaging and biochemical workflows.

Available Molecular Weight Variants

Specifications

Scientific Overview

Texas Redconjugated dextrans are hydrophilic fluorescent polysaccharides used extensively in cell biology, neuroscience, and imaging research. Their sizedependent diffusion properties make them ideal for studying membrane permeability, macropinocytosis, synaptic vesicle cycling, and intracellular trafficking. Larger dextrans (5002000 kDa) are commonly used to assess barrier integrity and extracellular diffusion, while smaller variants (320 kDa) are suited for endocytosis, vesicle labeling, and cytosolic tracking.

Common Research Applications

• Livecell and fixedcell fluorescence imaging
• Endocytosis and macropinocytosis assays
• Neuronal labeling and tracing
• Membrane permeability and barrier integrity studies
• Intracellular trafficking and vesicle dynamics
• Macromolecular diffusion and extracellular matrix transport

Usage & Handling Guidance

These conjugates are supplied as readytouse solutions. For experimental workflows, dilute in PBS, imaging buffer, or assayspecific media. Protect from light during handling and storage. Avoid repeated freezethaw cycles to maintain fluorescence intensity.

• Light sensitivity: Protect from light
• Storage: 20 C
• Avoid: repeated freezethaw cycles

What You Get

• 2.5 mg Texas Redconjugated dextran
• Eight molecular weight variants (32000 kDa)
• Sterilefiltered biotechnologygrade solution
• For research use only (RUO)

Frequently Asked Questions

• How do I choose the appropriate molecular weight?
  Smaller dextrans (320 kDa) are typically used for endocytosis, vesicle labeling, and intracellular tracking, while larger dextrans (702000 kDa) are preferred for barrier integrity, extracellular diffusion, and permeability studies.
• Is this product suitable for in vivo diagnostic or therapeutic use?
  No. These conjugates are for in vitro research use only and are not intended for diagnostic or therapeutic applications.
• Can I obtain a COA or TDS for a specific clone?
  Yes. COA/TDS availability is batch dependent. Please contact us to request documentation for the catalog and lot being shipped.
• Can these conjugates be used in livecell imaging?
  Yes. DextranTexas Red conjugates are widely used in livecell imaging workflows, provided that appropriate concentrations, buffers, and lightprotection practices are followed.

References

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• Morse SV et al. Neuron labeling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain via focused ultrasound. Theranostics. 2020 Feb 3;10(6):2659-2674.
• Siiman O et al. Fluorescent neoglycoproteins: antibody-aminodextran-phycobiliprotein conjugates. Bioconjug Chem. 1999 Nov-Dec;10(6):1090-106.
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• Adadja T, Cabana T, Pflieger JF. Cephalic sensory influence on forelimb movement in newborn opossums, Monodelphis domestica. Neuroscience. 2013 Jan 3;228:259-70.
• Lin L et al. Ultrasound-mediated DNA transformation in thermophilic gram-positive anaerobes. PLoS One. 2010 Sep 4;5(9):e12582.
• Zhao H et al. Inhibition of Megakaryocyte Differentiation by Antibody-Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC-induced Thrombocytopenia. Mol Cancer Ther. 2017 Sep;16(9):1877-1886.