Anti-GT1b Monoclonal Antibody

AntiGT1b Monoclonal Antibody Research Use Only

The AntiGT1b Monoclonal Antibody is a biotechnologygrade reagent targeting the ganglioside GT1b, a sialylated glycosphingolipid enriched in neuronal membranes. GT1b plays key roles in axonal stability, synaptic function, and neuroimmune interactions. This antibody is widely used in neuroimmunology, ganglioside profiling, GuillainBarr syndrome (GBS) research, and studies of glycosphingolipid distribution in the central and peripheral nervous systems. Each batch is produced to high purity and supplied as a liquid antibody preparation for reliable performance in analytical and immunological workflows.

Scientific Overview

GT1b is a complex ganglioside highly expressed in neuronal membranes, particularly in the brain and peripheral nerves. AntiGT1b antibodies are essential tools for studying ganglioside localization, glycosphingolipidmediated signaling, and autoimmune neuropathies. In GuillainBarr syndrome and related disorders, antiganglioside antibodiesincluding antiGT1bare associated with specific clinical presentations and electrophysiological patterns. This monoclonal antibody enables precise detection of GT1b in cells, tissues, and biochemical preparations.

Common Research Applications

• Detection of GT1b ganglioside in neuronal tissues
• Neuroimmunology and autoimmune neuropathy research
• GuillainBarr syndrome (GBS) and Miller Fisher syndrome studies
• Ganglioside profiling and glycosphingolipid analysis
• Immunostaining of neuronal membranes
• Biochemical assays involving gangliosideprotein interactions

Usage & Handling Guidance

Store at -80 C for longterm stability. Avoid repeated freezethaw cycles by aliquoting upon receipt. Thaw gently on ice before use. For best performance, use lowbinding tubes and maintain sterile technique.

• Storage: -80 C
• Handling: Aliquot to avoid freezethaw cycles
• Compatibility: Immunostaining, ELISA, dot blot, ganglioside binding assays

What You Get

• 50 g AntiGT1b Monoclonal Antibody
• Highpurity, biotechnologygrade reagent
• Batchspecific documentation available upon request
• For research use only (RUO)

Frequently Asked Questions

• What does this antibody recognize?
  This monoclonal antibody specifically recognizes the ganglioside GT1b, a sialylated glycosphingolipid enriched in neuronal membranes.
• Is this antibody suitable for immunostaining?
  Yes. It is commonly used for immunostaining neuronal tissues, cultured neurons, and gangliosiderich membrane preparations.
• Can this antibody be used in GuillainBarr syndrome research?
  Yes. AntiGT1b antibodies are frequently studied in the context of GBS, Miller Fisher syndrome, and related autoimmune neuropathies.
• Does this antibody crossreact with other gangliosides?
  Crossreactivity is batch dependent and should be evaluated experimentally. Contact us for available specificity data.
• How should the antibody be stored?
  Store at -80 C. Aliquot upon arrival to avoid freezethaw cycles.
• Is this antibody suitable for diagnostic use?
  No. This product is intended strictly for in vitro research use only (RUO).
• Can I request a COA or TDS?
  Yes. COA/TDS availability is batch dependent. Contact us with the catalog and lot number to request documentation.

References

• Schnaar RL et al. Antiganglioside antibody binding in differentiating oligodendrocytes. Glycobiology. 1996.
• Boffey J et al. Variable region gene usage in antiganglioside antibodies. J Neuroimmunol. 2005.
• Lunn MP et al. Highaffinity antiganglioside antibodies in knockout mice. J Neurochem. 2000.
• Fan X et al. Antibody responses to glycosphingolipids in knockout mice. Nagoya J Med Sci. 2011.
• Schnaar RL et al. Monoclonal antibodies to major brain gangliosides. Anal Biochem. 2002.
• Saha S, Mondal S. GT1b immunization studies. Indian J Exp Biol. 2000.
• Naik GS et al. Antiganglioside antibodies in GBS. Neurol India. 2017.
• Hsieh PF et al. AntiGT1b antibodies after stroke. Kaohsiung J Med Sci. 1998.
• Kinboshi M et al. GBS with antiGT1b antibodies. Rinsho Shinkeigaku. 2019.