ALK5 Extracellular Domain Human Recombinant
| Catalog number: | B2016873 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 50 g |
| Molecular Weight or Concentration: | 38.1 kDa |
| Supplied as: | Powder |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -80C |
| Keywords: | Activin Receptor-like Kinase 5, Serine/threonine Protein Kinase Receptor 4, SKR4, TGF-RI, Transforming Growth Factor Receptor Type I |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Zhang Y, Zhang J, Navrazhina K, Argaw AT, Zameer A, Gurfein BT, Brosnan CF, John GR. TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation Glia. 2010 Jun;58(8):964-74.
- Sridharan S, Nagarajan SK, Venugopal K, Venkatasubbu GD. Time-dependent conformational analysis of ALK5-lumican complex in presence of graphene and graphene oxide employing molecular dynamics and MMPBSA calculation J Biomol Struct Dyn. 2022 Aug;40(13):5932-5955.
- Pitou M, Papachristou E, Bratsios D, Kefala GM, Tsagkarakou AS, Leonidas DD, Aggeli A, Papadopoulos GE, Papi RM, Choli-Papadopoulou T. In Vitro Chondrogenesis Induction by Short Peptides of the Carboxy-Terminal Domain of Transforming Growth Factor 1 Biomedicines. 2023 Nov 29;11(12):3182.
- Santibanez JF, Prez-Gmez E, Fernandez-L A, Garrido-Martin EM, Carnero A, Malumbres M, Vary CP, Quintanilla M, Bernabu C. The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras Carcinogenesis. 2010 Dec;31(12):2145-54.
- Lai YT, Beason KB, Brames GP, Desgrosellier JS, Cleggett MC, Shaw MV, Brown CB, Barnett JV. Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation Dev Biol. 2000 Jun 1;222(1):1-11.
- Bhattacharyya S, Chen SJ, Wu M, Warner-Blankenship M, Ning H, Lakos G, Mori Y, Chang E, Nihijima C, Takehara K, Feghali-Bostwick C, Varga J. Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma Am J Pathol. 2008 Oct;173(4):1085-99.
- Harrison CA, Gray PC, Koerber SC, Fischer W, Vale W. Identification of a functional binding site for activin on the type I receptor ALK4 J Biol Chem. 2003 Jun 6;278(23):21129-35.
- Browne JA, Pearson AL, Zahr RA, Niculescu-Duvaz I, Baines DL, Dockrell ME. TGF-beta activates ERK5 in human renal epithelial cells Biochem Biophys Res Commun. 2008 Aug 29;373(3):440-4.
- Ungefroren H, Groth S, Ruhnke M, Kalthoff H, Fndrich F. Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta J Biol Chem. 2005 Jan 28;280(4):2644-52.
