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[Ala11, D-Leu15]-Orexin B (Human)
| Catalog number: | MDP0836 |
| CAS Number: | 186689-07-6 |
| Sequence: | Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-D-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
| Amount: | 100 ug |
| Molecular Weight: | 2857.2 g/mol |
| Supplied as: | Powder |
| Applications: | molecular tool for various biochemical applications |
| Storage: | -20 C |
| WARNING: | For in vitro Research Use Only. NOT for use on humans or animals. |
| Grade: | Biotechnology grade. All products are highly pure. |
References
- Asahi S, Egashira S, Matsuda M, Iwaasa H, Kanatani A, Ohkubo M, Ihara M, Morishima H. Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B Bioorg Med Chem Lett. 2003 Jan 6;13(1):111-3.
- Li TL, Chen JYS, Huang SC, Dai YE, Hwang LL. Cardiovascular pressor effects of orexins in the dorsomedial hypothalamus Eur J Pharmacol. 2018 Jan 5;818:343-350.
- Maehara S, Furukawa J, Ota T. Orexin 2 receptor is involved in orexin A-induced hyperlocomotion in rats Pharmacol Rep. 2019 Dec;71(6):1147-1150.
- Putula J, Turunen PM, Jntti MH, Ekholm ME, Kukkonen JP. Agonist ligand discrimination by the two orexin receptors depends on the expression system Neurosci Lett. 2011 Apr 20;494(1):57-60.
- Patel VH, Karteris E, Chen J, Kyrou I, Mattu HS, Dimitriadis GK, Rodrigo G, Antoniades C, Antonopoulos A, Tan BK, Hillhouse EW, Ng A, Randeva HS. Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection Clin Sci (Lond). 2018 Dec 13;132(24):2547-2564.
- Putula J, Turunen PM, Johansson L, Nsman J, Ra R, Korhonen L, Kukkonen JP. Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction FEBS Lett. 2011 May 6;585(9):1368-74.
- Maehara S, Yuge N, Higashi C, Ota T, Furukawa J, Takeuchi T. Pharmacological characterization of a novel potent, selective, and orally active orexin 2 receptor antagonist, SDM-878 Neuropsychopharmacol Rep. 2020 Jun;40(2):182-189.
- Guerreiro S, Florence C, Rousseau E, Hamadat S, Hirsch EC, Michel PP. The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine Mol Pharmacol. 2015;87(3):525-32.
- Lee HJ, Chang LY, Ho YC, Teng SF, Hwang LL, Mackie K, Chiou LC. Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray Neuropharmacology. 2016 Jun;105:577-586.
