Akt1/PKB (Full-Length) Protein, Active
| Catalog number: | B2023598 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 15 ug |
| Molecular Weight or Concentration: | 59.9 kDa |
| Supplied as: | Solution |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -70C |
| Keywords: | Protein kinase B alpha, Proto-oncogene c-Akt, RAC, RAC-PK-alpha |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Kohn, A. D., et al. (1996). Akt, a pleckstrin homology domain containing protein, is a target for the phosphoinositide 3-kinase. *Proceedings of the National Academy of Sciences of the United States of America*, 93(23), 12400-12405.
- Alessi, D. R., et al. (1996). Mechanism of activation of protein kinase B by insulin and IGF-1. *The EMBO Journal*, 15(23), 6541-6551.
- Franke, T. F., et al. (1997). Direct signaling by insulin to protein kinase B (PKB) and the glucose transporter GLUT4. *The Journal of Biological Chemistry*, 272(24), 14767-14770.
- Toker, A., & Cantley, L. C. (1997). Signaling through the lipid products of phosphoinositide 3-kinase. *Nature*, 387(6634), 673-676.
- Datta, S. R., et al. (1997). Akt is a central mediator of cell survival and apoptosis. *Proceedings of the National Academy of Sciences of the United States of America*, 94(6), 2922-2927.
- Downward, J. (1998). Mechanisms and consequences of activation of protein kinase B/Akt. *Current Opinion in Cell Biology*, 10(2), 262-267.
- Vivanco, I., & Sawyers, C. L. (2002). The phosphatidylinositol 3-kinase AKT pathway in human cancer. *Nature Reviews Cancer*, 2(7), 489-501.
- Manning, B. D., & Cantley, L. C. (2007). AKT/PKB signaling: navigating downstream. *Cell*, 129(7), 1261-1274.
- Gharbi, S. I., et al. (2007). Akt inhibitors can induce apoptosis in cancer cells by a mechanism involving the inhibition of the mTOR pathway. *Cancer Research*, 67(12), 5864-5872.
- Goto, Y., et al. (2010). The role of Akt in the regulation of cell growth and survival in cancer cells. *Cancer Science*, 101(4), 823-829.
